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Understanding FFPE Tissue Samples: Preserving the Past, Shaping the Future of Medical Science
In the quiet corners of laboratories and pathology departments around the world, a powerful story is silently unfolding—one that begins with a biopsy and stretches into decades of discovery. It’s the story of FFPE tissue samples—formalin-fixed, paraffin-embedded specimens—that have become the silent custodians of our cellular history. Though they sit tucked away in slides and blocks, these samples are vital to modern diagnostics, personalized medicine, and groundbreaking research.
What Are FFPE Tissue Samples?
To the untrained eye, FFPE might sound like another acronym in the sea of medical jargon. But for researchers, pathologists, and oncologists, FFPE samples are invaluable tools. The process starts when a tissue sample, such as a tumor biopsy, is preserved by fixing it in formalin to halt cellular decay. This tissue is then embedded in paraffin wax, stabilizing it for long-term storage.
This method,…
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Atopic dermatitis (AD) drugs are used to manage and treat atopic dermatitis, a chronic inflammatory skin condition characterized by itching, redness, dryness, and flare-ups. Treatment options are designed to reduce inflammation, relieve itching, prevent infections, and repair the skin barrier. Commonly used drugs include topical corticosteroids and calcineurin inhibitors for controlling mild to moderate symptoms, and systemic therapies such as oral corticosteroids, cyclosporine, and methotrexate for severe cases. In recent years, biologic drugs like dupilumab and tralokinumab, which target specific immune pathways, have revolutionized the management of moderate to severe atopic dermatitis by providing more targeted and effective treatment options with fewer side effects compared to traditional systemic drugs.
The choice of therapy often depends on the severity of the condition, patient age, and response to previous treatments. In addition to prescribed medications, antihistamines may be used to relieve itching, and antibiotics are sometimes necessary to treat secondary skin infections caused by scratching. The market for atopic dermatitis drugs is expanding rapidly due to the rising prevalence of the disease globally and the growing adoption of advanced biologics and Janus kinase (JAK) inhibitors like upadacitinib and abrocitinib. Research continues to focus on developing safer and more effective treatments that provide long-term disease control and improve patients’ quality of life.
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